Cisplatin dna repair
WebAccording to M. Uehara et al., ATM inhibition worsens tubular injury via upregulating p53-dependent pro-apoptotic signaling and does not enhance DNA repair following cisplatin … Web1 day ago · It activates DNA repair, elevates PCNA expression and inactivates DNA-damaging agents, thus having a protective effect against oxidative DNA damage [24], …
Cisplatin dna repair
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WebNational Center for Biotechnology Information WebLTTs recovered rapidly from cisplatin stress compared to parental cells. In LTTs, to various extents, cisplatin exporters and metallothioneins were induced, cisplatin adduct levels and DNA damage were decreased, whereas expression of DNA repair factors and specific anti-apoptotic factors was elevated.
WebNov 14, 2012 · To repair the lesions, cells perform a DNA-damage response that includes chromatin remodeling, activation of cell-cycle checkpoints, DNA repair and, allowing time for the DNA repair to occur. If the responses fail, cells undergo apoptosis as a last resort to sustain genomic stability. WebDec 4, 2024 · Cisplatin is a chemotherapeutic drug used for the treatment of a number of cancers. The efficacy of cisplatin relies on its binding to DNA and the induction of cytotoxic DNA damage to kill cancer cells. Cisplatin-based therapy is best known for curing testicular cancer; however, treatment of other solid tumors with cisplatin has not been as …
WebMar 9, 2024 · The strategy of tuning both apoptosis and DNA repair pathways opens a promising window to overcoming resistance to cisplatin in anticancer chemotherapy, and is also a breakthrough in the design of multitalented platinum-based anticancer drugs. WebTo clarify the HMGB1 role for DNA repair of cisplatin damages in vivo, we studied the effect of HMGB1 overexpression on the DNA repair. Further experiments were carried …
WebApr 14, 2024 · For platinum derivatives, the situation is more complex as the repair of the cytotoxic lesions induced by cisplatin is not enhanced by PARP inhibitors in HR-proficient cells . Furthermore, the platinum-induced DNA crosslinks are repaired by transcription-coupled nucleotide excision repair (TC-NER) and translesion synthesis independently of …
WebNov 1, 2024 · Post-surgical radiation and cisplatin-based chemotherapy have been a mainstay of treatment, which often leads to substantial neurocognitive impairments and … css overflow:scrollWebCisplatin, a tiny molecule with platinum bound to two amines and two chlorides, is exactly this type of game changer: in the mid-1970s, is was found to be highly effective in treating testicular cancers. Cisplatin … css overflow inheritWebAug 1, 2024 · Cisplatin treatment mainly induces intra- and interstrand DNA cross-links. These lesions are repaired by NER. Low expression of NER related proteins (e.g. ERCC1, XPF and XPA) are a rate limiting factor for cisplatin-DNA cross-link repair. High expression of HMGB1/4 can inhibit NER. earls house county industrial schoolWebMar 3, 2008 · There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break … earls houseWeb2 days ago · This is because the cytostatic drug causes damage to DNA, the carrier of genetic information, thus stopping the cell cycle. The alarm signal is sent 'Attention, repair, do not divide further.' css overflow scroll verticalWebSep 1, 2002 · NER 3 is the main mechanism for removing cisplatin adducts. NER has been elucidated at the molecular level in recent years, and it is now possible to follow step by step the repair of adducts and cross-links on adjacent DNA bases .The NER molecular machinery includes well-defined proteins that are mutated in XP and CS patients .NER … css overflow scrollableWebJan 18, 2024 · Two major nucleotide excision repair pathways, transcription-coupled repair (TCR) and global repair (GR), are well known to remove cisplatin-induced DNA … earls house lanchester road