Cisplatin treatment for oropharyngeal cancer

Author: grgl

August undefined, 2024

WebOct 1, 2024 · Cetuximab represents a potential option for those ineligible for cisplatin or, until recently, an agent for de-escalation in low risk HPV+ oropharyngeal carcinoma (OPSCC). Our objective was to... WebMay 27, 2024 · The majority of newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV) infection, portending very good …

Radiotherapy plus cisplatin or cetuximab in low-risk human papillo…

WebWe found no significant differences in survival or grade ≥ 3 side effects comparing simultaneous integrated boost and brachytherapy boost as alternative dose escalation modalities in the treatment of oropharyngeal cancer. Supplementary Information The online version contains supplementary material available at 10.1186/s13014-023-02256-x. WebOct 1, 2013 · Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy with radiation therapy may kill more tumor cells. how to save my downloads

Head and Neck Cancers, Version 2.2024, NCCN Clinical …

WebNov 15, 2024 · Cisplatin chemotherapy can bring lasting adverse health effects, but a new, presumably less-toxic alternative is not as effective at promoting survival, according to a large, Stanford-led trial. Traditional … WebThe treatment of locally advanced head and neck cancer (HNC) is based on extensive resections followed by concurrent chemoradiotherapy (CRT) with platinum derivatives or concurrent radiotherapy with cetuximab (bioradiotherapy; BRT). Malnutrition, which occurs in up to 60% of patients before treatment commencement, severely increases the risk of … WebFeb 2, 2024 · The benefit of adding concomitant high-dose cisplatin to adjuvant radiotherapy (RT) for resected head and neck squamous cell carcinoma (HNSCC) was established in two large seminal trials, EORTC 22931 and RTOG 9501. 1 - 3 In these studies, cisplatin was administered at a dose of 100 mg/m 2 on days 1, 22, and 43 … how to save my facebook account

Cisplatin and Durvalumab and Radiotherapy on Oropharyngeal Cancer ...

Less Treatment for HPV-Related Oropharyngeal Cancer - NCI

WebApr 7, 2024 · Local recurrence is the most common pattern of failure in head and neck cancer. It can therefore be hypothesised that some of these patients would benefit from an intensified local treatment, such as radiation dose escalation of the primary tumour. This study compares treatment and toxicity outcomes from two different boost modalities in … WebCisplatin is called the “penicillin of cancer” because it is used so widely and it was the first big chemotherapy drug. Cisplatin also plays an interesting role in the history of … north face paddingWebApr 15, 2024 · The trial will directly compare clinical outcomes related to de-intensification strategies in HPV-positive oropharyngeal disease through use of both reduced intensity radiation and/or nivolumab therapy. Similar to NRG-HN004 in cisplatin-ineligible patients, immune checkpoint therapy is added to augment RT-induced immunogenic cell death … how to save my elvui profile

"WebOct 1, 2024 · All OPSCC patients were treated either with definitive cisplatin-chemoradiotherapy (CRT) or with definitive radiotherapy (RT) based on standard clinical … " - Cisplatin treatment for oropharyngeal cancer

Cisplatin treatment for oropharyngeal cancer

Treatment De-intensification for HPV-Positive Oropharynx Cancer: …

WebApr 11, 2024 · Eisenberger M, Hornedo J, Silva H, et al. Carboplatin (NSC-241-240): an active platinum analog for the treatment of squamous-cell carcinoma of the head and neck. J Clin Oncol 1986; 4:1506. Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008; 359:1116. http://www.nrgoncology.org/Home/News/Post/treatment-de-intensification-for-early-stage-hpv-positive-oropharyngeal-cancer-nrg-hn005

Did you know?

WebSep 15, 2024 · Aluminum reacts with cisplatin (cisplatin injection) , causing precipitate formation and a loss of potency. Metastatic Testicular Tumors - The usual cisplatin … WebOct 22, 2024 · This study shows that the best treatment choice for patients with HPV-positive throat cancer is cisplatin and radiotherapy. This combination gives ‘double’ the benefit since it is more effective in terms of survival and does not worsen all grade toxicity compared to cetuximab with radiotherapy.”

WebAug 5, 2024 · This growing evidence supports cisplatin-based radiotherapy as the standard of care for patients with HPV/p16-positive cancer with low risk (e.g. non-smokers or < 10 pack-years smoking history) [ 9 ]. We also found the survival benefit with cisplatin therapy to be consistent among those who smoke and those with advanced age. WebNov 10, 2024 · Patients were generally treated with concurrent high dose cisplatin (100 mg/m 2 given every three weeks), excluding patients aged ≥ 70, those with comorbidities or poor performance status or those who declined. Weekly cisplatin (40 mg/m 2) could be used at the discretion of the medical oncologist.

WebJan 7, 2024 · Cisplatin treatment was administered as a triweekly regimen, which differs from this study where weekly, low-dose treatment was used. There was a significantly … WebApr 12, 2024 · The association of cisplatin pharmacokinetics and skeletal muscle mass in patients with head and neck cancer: the prospective PLATISMA study. Eur. J. Cancer 160, 92–99 (2024). •• Pivotal study investigating the mechanism of cisplatin toxicity in sarcopenia.Crossref, Medline, CAS, Google Scholar; 46. Lutz CT, Quinn LS.

WebJun 6, 2024 · Results of our study show that, in the setting of low-risk oropharyngeal squamous cell carcinoma, the use of cetuximab bioradiotherapy instead of cisplatin-based chemoradiotherapy resulted in no overall benefit in terms of toxicity but showed significant detriment in tumour control.

WebDec 3, 2024 · The oropharyngeal areas mainly comprises of the tonsil, base tongue (BOT), soft palate and the posterior pharyngeal wall. Traditionally, surgical resection of oropharyngeal cancers (OPC) was a standard procedure, often performed through mutilating incisions with mandibulotomies, rendering significant post-operative functional … north face padded jacket women longWebNov 11, 2024 · Performance status, higher N stage, HPV status, and use of cisplatin were associated with better PFS on univariable analysis (eTable 3 in the Supplement). On multivariable analysis, only KPS (HR, 0.90; ... and volumetric modulated arc therapy (VMAT) for the treatment of oropharyngeal cancer. Radiother Oncol. 2024;147:64-74. doi: ... how to save my documentsWebFeb 21, 2024 · Although de-intensification strategies have been propelled to the forefront of clinical research in human papillomavirus (HPV) positive oropharyngeal cancer, three … north face padded slippersWebOropharyngeal Cancer—Lessons Learnt from Recent Trials Hisham Mehanna Introduction Human papillomavirus (HPV)—mediated oropharyngeal cancer (OPC) has been ... it is … north face padded jacket with hoodWebJul 1, 2024 · Treatment is complex for patients with head and neck (H&N) cancers with specific site of disease, stage, and pathologic findings … north face padded coat womenWebJan 7, 2024 · Cisplatin treatment was administered as a triweekly regimen, which differs from this study where weekly, low-dose treatment was used. There was a significantly increased risk of grade 3 increase in serum-creatinine (3.0 to 6.0 times the upper limit of normal serum-creatinine) in the saline group. how to save my emailWebOropharyngeal Cancer—Lessons Learnt from Recent Trials Hisham Mehanna Introduction Human papillomavirus (HPV)—mediated oropharyngeal cancer (OPC) has been ... it is widely acknowledged that treatment with cisplatin increases the number of acute serious toxicities by a factor of two, compared to radiotherapy alone [4]. It also demonstrates ... how to save my files